DISCOVERY OF O-LINKED CARBOHYDRATE ON HIV-1 ENVELOPE AND ITS ROLE IN SHIELDING AGAINST ONE CATEGORY OF BROADLY NEUTRALIZING ANTIBODIES

Discovery of O-Linked Carbohydrate on HIV-1 Envelope and Its Role in Shielding against One Category of Broadly Neutralizing Antibodies

Summary: Approximately 50% of the mass of the Envelope (Env) glycoprotein surface subunit (gp120) of human immunodeficiency virus type 1 (HIV-1) is composed of N-linked carbohydrate.Until now, the dogma has been that HIV-1 lacks O-linked carbohydrate on Env.Here we show that a subset of patient-derived HIV-1 isolates contain O-linked carbohydrate o

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Predisposing, Enabling, and Reinforcing Factors of COVID-19 Prevention Behavior in Indonesia: A Mixed-methods Study

Objectives: To prevent the spread of coronavirus disease 2019 (COVID-19), behaviors such as mask-wearing, social distancing, decreasing mobility, and avoiding crowds have been suggested, especially in high-risk countries such as Indonesia.Unfortunately, the level of compliance with those practices has been low.This study was conducted catherine lan

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