Discovery of O-Linked Carbohydrate on HIV-1 Envelope and Its Role in Shielding against One Category of Broadly Neutralizing Antibodies
Summary: Approximately 50% of the mass of the Envelope (Env) glycoprotein surface subunit (gp120) of human immunodeficiency virus type 1 (HIV-1) is composed of N-linked carbohydrate.Until now, the dogma has been that HIV-1 lacks O-linked carbohydrate on Env.Here we show that a subset of patient-derived HIV-1 isolates contain O-linked carbohydrate o